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KMID : 0617220020130010099
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Duksung Bulletin Phamaceutical Sciences
2002 Volume.13 No. 1 p.99 ~ p.103
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Crystal Form of A Camptothecin Derivative
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Abstract
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Three polymorphic modifications of CKD-602, water soluble derivative of camptothecin, were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC). thermogravimetric analysis (TGA) and X-ray powder diffraction (XRPD). The major endothermic peaks of the DSC curve of Form 1, Form 2 and Form 3 was shown at 268.71℃, 247.83℃, 244.76℃, respectively. Form 2 was elucidated to be an acctic acid solvate and Form 3 was elucidated to be a methanol solvate. The dissolution patterns of these three modifications were also checked in distilled water at 37±0.5℃, for 30 minutes. The polymorphic modifications showed differences in the dissolution rate. The dissolution rate of Form 1 was faster than that of other polymorphic modifications. When stored at different relative humidity over the period of 3 months. all of the polymorphic modifications did not undergo transformation.
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